Tricky isn't it? You have to be sure when you attack. Communications can be important for turning your fleet around should a defense fleet be discovered or you find they have developed a new armor or weapons tech while enroute.Strategic puts some interesting challenge for a Blitz, mainly the absence of retreat option.
In tactical if you arrive with some minimum nuke-boats, if defender suddenly has ECM or some other new tech, you can just retreat and come back with an extra CA. In Strategic, if an opponent completes a tech upon your arrival or his crew level goes up by one, suddenly you can lose much more ships, or worse even the whole fleet can be lost.
Also, as a zero-loss combat does not happen often at all, throughout the entire game you must keep spending resources on building ships to keep the minimum fleet in tact.
In vanilla I used to overwhelm starbases with quickly constructed space academy trained destroyer fleets with Warlord in the beginning of the game.